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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TPH1 All Species: 43.64
Human Site: S346 Identified Species: 73.85
UniProt: P17752 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P17752 NP_004170.1 444 50985 S346 S E L K H A L S G H A K V K P
Chimpanzee Pan troglodytes XP_001172877 875 97166 S346 S E L K H A L S G H A K V K P
Rhesus Macaque Macaca mulatta Q2HZ26 490 56076 S392 G E L K H A L S D K A C V K A
Dog Lupus familis XP_854768 828 92147 S387 S E L K H S L S G H A K V K P
Cat Felis silvestris
Mouse Mus musculus P17532 447 51325 S349 S E L K H A L S G H A K V K P
Rat Rattus norvegicus P09810 444 51050 S346 S E L R H A L S G H A K V K P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519524 444 50785 S346 G E L K H A L S G L A K V K P
Chicken Gallus gallus P70080 445 51121 S347 S E L K H S L S G S A K V K P
Frog Xenopus laevis Q92142 481 55388 S383 S E L K H S L S G N A K V K P
Zebra Danio Brachydanio rerio NP_840091 471 53899 G372 K L R A Y G A G L L S S I S E
Tiger Blowfish Takifugu rubipres NP_001027848 479 54964 S381 S E L K H A L S G N A R I M P
Fruit Fly Dros. melanogaster P17276 452 51642 E354 L S S Y G E L E Y C L T D K P
Honey Bee Apis mellifera XP_394674 508 57954 S386 A E L K H A V S V P E K T F R
Nematode Worm Caenorhab. elegans P90925 457 52111 S359 G E L Q Y A L S D K P E V V D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 50.5 64.6 52.5 N.A. 89.4 91.2 N.A. 85.3 85.8 75.2 72.8 71.6 51.1 57.2 48.3 N.A.
Protein Similarity: 100 50.6 79.3 53.1 N.A. 95.3 96.1 N.A. 93.6 95.5 87.3 83.6 84.1 71.4 71.6 68 N.A.
P-Site Identity: 100 100 66.6 93.3 N.A. 100 93.3 N.A. 86.6 86.6 86.6 0 73.3 20 46.6 40 N.A.
P-Site Similarity: 100 100 66.6 100 N.A. 100 100 N.A. 86.6 93.3 100 20 93.3 20 60 60 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 8 0 65 8 0 0 0 72 0 0 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 8 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 15 0 0 0 8 0 8 % D
% Glu: 0 86 0 0 0 8 0 8 0 0 8 8 0 0 8 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % F
% Gly: 22 0 0 0 8 8 0 8 65 0 0 0 0 0 0 % G
% His: 0 0 0 0 79 0 0 0 0 36 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 15 0 0 % I
% Lys: 8 0 0 72 0 0 0 0 0 15 0 65 0 72 0 % K
% Leu: 8 8 86 0 0 0 86 0 8 15 8 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 15 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 8 8 0 0 0 72 % P
% Gln: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 8 8 0 0 0 0 0 0 0 8 0 0 8 % R
% Ser: 58 8 8 0 0 22 0 86 0 8 8 8 0 8 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 8 8 0 0 % T
% Val: 0 0 0 0 0 0 8 0 8 0 0 0 72 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 8 15 0 0 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _